Unveiling Geneious: The Ultimate Review

Geneious is one of the most famous bioinformatics software programs. It is used by various researchers, from molecular biologists to bioinformaticians, from wet lab scientists with minimal coding experience to seasoned bioinformaticians. This review will discuss every product Geneious has and is providing to its users. It will also discuss Geneious’s strengths, weaknesses, and pricing. Keep reading the blog to learn everything. 

Geneious products

It offers two different types of products: Geneious Prime and Geneious Biologics. In this blog, we will inform you about all the products Geneious Prime and Geneious Biologics offer users. 

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Geneious Prime

Prime is about leading molecular biology and sequence analysis bioinformatics tools for researchers. Let’s discuss the products Prime is providing. 

Mapping & de novo assembly

Clean, processed data is essential for accurately performing downstream assembly. Using necessary pre-processing tools will provide accurate data. You can demultiplex/ split your NGS data by barcoding it, trim adaptors, merge paired reads, de-duplicate, correct errors, and filter out chimeras. Geneious assembler is flexible enough to handle data from any sequencing machine with reads of any length. 

Sanger sequence analysis 

You can automatically annotate a genome sequence based on existing patterns and annotations in public or local databases, including annotating ORFs as hypothetical genes based on their patterns and queries against NCBI. You can even annotate with similarity. You can make real-time sequence predictions, including DNA translation, consensus, and protein sequences. 

Variant calling & expression analysis 

With just a few clicks, you can get effortless visualization. You can even get robust SNP variant analysis from the versatile algorithm or FreeBayes. You can also use external pipelines for variant calls. You don’t need R expertise; use the industry-standard DESeq2 package to compare expressions between two conditions. You can assemble filters and analyze metagenomics datasets. 

Phylogenetics 

Geneious has an all-in-one system for phylogenetic tree-making. You don’t need to juggle between files to create a phylogenetic tree. You can choose an algorithm to create a phylogenetic tree. After completion, you can easily export the file to publish your work. 

Microsatellite analysis 

With Geneious, you can get streamlined access to a messy amount of microsatellite analysis. With the CSV file exporter, you can easily export an allele table view to your system. 

Primer design & testing

Geneious has a built-in primer database and browser. Drag and drop primers in FASTA, spreadsheet, or GenBank format. Even Prime will let you know if you have already added those primers. It also has a primer design tool. You can get to test the primers. Before ordering, you can test PCR primers.  

Data management & collaboration 

It has everything a researcher needs. It allows you to easily manage every file type, import metadata from a spreadsheet onto sequences and other documents, sort all your project files in one place, and easily integrate a shared database. With an extensive export option, this is your one-stop option. 

Automated workflows

With this, you can create workflows for automated bulk analysis using a visual editor. You will get more than 20 built-in workflows for performing pipelines, which include variant applications to reference sequences and map reads, and then find SNPs and randomly sample sequences. You can even custom-write code workflows. 

API & developer 

Use the plugin development kit to integrate with other systems. You can add your favorite algorithm, database, or visualization. You can wrap a command-line program to run via the Geneious Prime GUI. 

Why use Geneious Prime?

1. Prime has a very easy-to-use interface. It is best for wet lab scientists who have minimal bioinformatics experience. 
2. Prime has an excellent visualization feature best suited for teachers who want to help students learn about complex topics. 
3. With exploratory analysis tools, researchers can efficiently generate hypotheses. 

Geneious biologics 

It has the most extensive cloud-based antibody discovery solution. Let’s discuss the products of biologics. 

Antibody centric analysis 

It offers a comprehensive set of tools for antibody analysis. This includes sequence annotation, visualization of antibody structure, and identification of functionality-similar sequences. 

High throughput NGS 

The software assembly allows the researcher to integrate seamlessly and efficiently with a large set of NGS datasets of antibody sequences. 

Statistical trends identification 

You can easily compare and identify frequencies and dominant clones with a large set of samples. You can also choose how to cluster data according to your preferences and regions of interest and quickly generate tables. 

Collaboration 

In Biologics, you will get collaboration features and Prime with secure data sharing and collaboration within your research teams. 

Why use Geneious biologics?

1. For researchers working on antibody development as therapeutics or diagnostics, biologics is a powerful tool with extensive work power. 
2. Immunologists who are working studying antibody repositories & immune responses can utilize biologics the most. 

Geneious prime & biologics strengths 

1. Prime’s most significant advantage is its user-friendly interface. Many wet lab researchers have limited exposure to bioinformatics tools, so they can easily use Prime. 
2. Biologics offers an antibody-centric interface and workforce. 
3. It is a one-stop solution for sequence assembly and annotation, variant calling, and phylogenetic analysis; it is basically a broad-spectrum bioinformatics tool. 
4. Cater to single-cell antibody discovery workflows by analyzing individual cells.
5. It offers interactive & informative visualizations of alignments, variants, and phylogenetic trees that enhance exploration and understanding. 
6. Provides a wide range of applications along with support from the team. 
7. You will get secure data sharing and project collaboration features to facilitate teamwork and accelerate research progress. 

Geneious prime & biologics weakness

1. Prime & Biologics requires a full-time paid license. The pay range is relatively high, which might be a hurdle for students. 
2. Prime might not be the best tool to handle large NGS datasets. 
3. Biologics is a cloud-based platform. It might be a limitation for restricted access researchers. 

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Pricing

1. Geneious Prime includes team subscriptions for both academic and corporate. For two users, the price is $1280; for five, it is $3200; for ten, it is $6400. The corporate price is, for two users, $4500; for 5, it is $11250; for ten users, it is $22500. 
2. Geneious Biologics has three types of pricing. The starter plan is free for a week. To continue more, you must buy a personal plan for $9000 for the corporate and $4500 for the academic. Another plan is a group plan, which is custom; you have to contact Geneious to know more about it. 

Bottom Line

If your research involves general bioinformatics tasks like sequence analysis, variant calling, or phylogenetic studies, then Geneious Prime is best suited. 

If your research involves antibody discovery, development, and analysis, Geneious biologics is best suited for your research team. 

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